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Human Cytomegalovirus UL131 Open Reading Frame Is Required for Epithelial Cell Tropism

28 Jul 2005

Abstract excerpt

Epithelial cells are one of the prominent cell types infected by human cytomegalovirus (HCMV) within its host. However, many cultured epithelial cells, such as ARPE-19 retinal pigmented epithelial cells, are poorly infected by laboratory-adapted strains in cell culture, and little is known about the viral factors that determine HCMV epithelial cell tropism. In this report, we demonstrate that the UL131 open...

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PMID: 16051825
DOI: 10.1128/jvi.79.16.10330-10338.2005

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