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Article

Analysis of Hepatitis C Virus NS5A Region in Patients with Cirrhosis Using an Ultra-Deep Pyrosequencing Method.

Clinical laboratory - 1 Sept 2017

Keskin Fahriye, Ciftci Sevgi, Akyuz Filiz, Abaci Neslihan, Cakiris Aris, Akyuz Umit, Demir Kadir, Besisik Fatih, Ustek Duran, Kaymakoglu Sabahattin

Abstract excerpt

BACKGROUND: HCV (Hepatitis C Virus) is genetically more diverse than HBV and HIV (Human Immunodeficiency Virus) and exists as quasispecies within infected individuals. This is due to the lack of efficient proofreading of the viral RNA-dependent RNA polymerase. Consequently, quasispecies emerge depending on the mutation rate of the viral polymerase, which may display a high level of genetic variability in a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28879707
DOI: 10.7754/Clin.Lab.2017.170312

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