Article
Next-Generation Sequencing of 5' Untranslated Region of Hepatitis C Virus in Search of Minor Viral Variant in a Patient Who Revealed New Genotype While on Antiviral Treatment.
Advances in experimental medicine and biology - 1 Jan 2016
Caraballo Cortes Kamila, Bukowska-Ośko Iwona, Pawełczyk Agnieszka, Perlejewski Karol, Płoski Rafał, Lechowicz Urszula, Stawiński Piotr, Demkow Urszula, Laskus Tomasz, Radkowski Marek
Abstract excerpt
The role of mixed infections with different hepatitis C virus (HCV) genotypes in viral persistence, treatment effects, and tissue tropism is unclear. Next-generation sequencing (NGS), which is suitable for analysis of large, genetically diverse populations offers unparalleled advantages for the study of mixed infections. The aim of the study was to determine, using two different deep sequencing strategies...
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