Article
Amplification and pyrosequencing of near-full-length hepatitis C virus for typing and monitoring antiviral resistant strains.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 May 2016
Trémeaux P, Caporossi A, Ramière C, Santoni E, Tarbouriech N, Thélu M-A, Fusillier K, Geneletti L, François O, Leroy V, Burmeister W P, André P, Morand P, Larrat S
Abstract excerpt
Directly acting antiviral drugs have contributed considerable progress to hepatitis C virus (HCV) treatment, but they show variable activity depending on virus genotypes and subtypes. Therefore, accurate genotyping including recombinant form detection is still of major importance, as is the detection of resistance-associated mutations in case of therapeutic failure. To meet these goals, an approach to amplify the...
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