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Article

Comparison of next-generation sequencing and clone-based sequencing in analysis of hepatitis B virus reverse transcriptase quasispecies heterogeneity.

Journal of clinical microbiology - 1 Dec 2013

Gong Ling, Han Yue, Chen Li, Liu Feng, Hao Pei, Sheng Jia, Li Xin-Hua, Yu De-Min, Gong Qi-Ming, Tian Fei, Guo Xiao-Kui, Zhang Xin-Xin

Abstract excerpt

We previously reported that, based on clone-based sequencing (CBS), hepatitis B virus (HBV) heterogeneity within the reverse transcriptase (RT) region was a predictor of antiviral efficacy. Here, by comparing ultradeep pyrosequencing (UDPS), i.e., next-generation sequencing (NGS), with CBS in characterizing the genetic heterogeneity of HBV quasispecies within the RT region, we evaluated the performance of UDPS in...

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Identifiers

PMID: 24088859
DOI: 10.1128/JCM.01723-13
PMCID: PMC3838070

Genes

CBS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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