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Article

Structural basis for CRMP2-induced axonal microtubule formation.

Scientific reports - 6 Sept 2017

Niwa Shinsuke, Nakamura Fumio, Tomabechi Yuri, Aoki Mari, Shigematsu Hideki, Matsumoto Takashi, Yamagata Atsushi, Fukai Shuya, Hirokawa Nobutaka, Goshima Yoshio, Shirouzu Mikako, Nitta Ryo

Abstract excerpt

Microtubule associated protein Collapsin response mediator protein 2 (CRMP2) regulates neuronal polarity in developing neurons through interactions with tubulins or microtubules. However, how CRMP2 promotes axonal formation by affecting microtubule behavior remains unknown. This study aimed to obtain the structural basis for CRMP2-tubulin/microtubule interaction in the course of axonogenesis. The X-ray structural...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28878401
DOI: 10.1038/s41598-017-11031-4
PMCID: PMC5587665

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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