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Article

Activated Protein C Attenuates Severe Inflammation by Targeting VLA-3high Neutrophil Subpopulation in Mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2017

Sarangi Pranita P, Lee Hyun-Wook, Lerman Yelena V, Trzeciak Alissa, Harrower Eric J, Rezaie Alireza R, Kim Minsoo

Abstract excerpt

The host injury involved in multiorgan system failure during severe inflammation is mediated, in part, by massive infiltration and sequestration of hyperactive neutrophils in the visceral organ. A recombinant form of human activated protein C (rhAPC) has shown cytoprotective and anti-inflammatory functions in some clinical and animal studies, but the direct mechanism is not fully understood. Recently, we reported...

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Source

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Identifiers

PMID: 28877991
DOI: 10.4049/jimmunol.1700541
PMCID: PMC5658029

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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