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Article

The Ashwell receptor mitigates the lethal coagulopathy of sepsis.

Nature medicine - 1 Jun 2008

Grewal Prabhjit K, Uchiyama Satoshi, Ditto David, Varki Nissi, Le Dzung T, Nizet Victor, Marth Jamey D

Abstract excerpt

The Ashwell receptor, the major lectin of hepatocytes, rapidly clears from blood circulation glycoproteins bearing glycan ligands that include galactose and N-acetylgalactosamine. This asialoglycoprotein receptor activity remains a key factor in the development and administration of glycoprotein pharmaceuticals, yet a biological purpose of the Ashwell receptor has remained elusive. We have identified endogenous...

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Source

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Identifiers

PMID: 18488037
DOI: 10.1038/nm1760
PMCID: PMC2853759

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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