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Article

New players in the sepsis-protective activated protein C pathway

16 Aug 2010

Abstract excerpt

Recombinant activated protein C (aPC) improves the survival of patients with severe sepsis, but the precise molecular and cellular targets through which it mediates this effect remain incompletely understood. In this issue of the JCI, Kerschen et al. show that endothelial cell protein C receptor (EPCR) is specifically expressed by mouse CD8+ dendritic cells and that these coordinators of host responses to...

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Share to Blood Coagulation and Thrombosis Mechanisms
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PMID: 20714106
DOI: 10.1172/jci44266

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