Article

The ‘C3aR antagonist’ SB290157 is a partial C5aR2 agonist

2020-08-03

Abstract excerpt

<h4>ABSTRACT</h4> Innate immune complement activation generates the C3 and C5 protein cleavage products C3a and C5a, defined classically as anaphylatoxins. C3a activates C3a receptors (C3aR), while C5a activates two receptors (C5aR1 and C5aR2) to exert their immunomodulatory activities. The non-peptide compound, SB290157, was originally reported in 2001 as the first C3aR antagonist. In 2005, the first report on n...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1f3572d6-625f-51cd-a85c-40250353781f
DOI: 10.1101/2020.08.01.232090

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The ‘C3aR antagonist’ SB290157 is a partial C5aR2 agonistDOI 10.1101/2020.08.01.232090Read

Structural insights into agonist-binding and activation of the human complement C3a receptorSemantic proximity Read

The Complement C5a-C5aR1 GPCR Axis in COVID-19 TherapeuticsSemantic proximity Read

Partial ligand-receptor engagement yields functional bias at the human complement receptor, C5aR1Semantic proximity Read

The anaphylatoxin C5a: Structure, function, signaling, physiology, disease, and therapeuticsSemantic proximity Read

Compstatin: a C3‐targeted complement inhibitor reaching its prime for bedside interventionSemantic proximity Read

Chimeric receptors of the human C3a receptor and C5a receptor (CD88).Semantic proximity Read

Complement C5 inhibition in patients with COVID-19 - a promising target?Semantic proximity Read

A study of the molecular pharmacological properties of C5a and C5a des Arg : defining their biased agonist profile and contrasting biological functionSemantic proximity Read

Complement Inhibition with the C5 Blocker LFG316 in Severe COVID-19Semantic proximity Read

Compstatins: the dawn of clinical C3-targeted complement inhibitionSemantic proximity Read

The Promiscuous Profile of Complement Receptor 3 in Ligand Binding, Immune Modulation, and PathophysiologySemantic proximity Read

Molecular mechanism of naturally-encoded signaling-bias at the complement anaphylatoxin receptorsSemantic proximity Read