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Article

α-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8.

The Journal of clinical investigation - 1 Dec 2010

Bergin David A, Reeves Emer P, Meleady Paula, Henry Michael, McElvaney Oliver J, Carroll Tomás P, Condron Claire, Chotirmall Sanjay H, Clynes Martin, O'Neill Shane J, McElvaney Noel G

Abstract excerpt

Hereditary deficiency of the protein α-1 antitrypsin (AAT) causes a chronic lung disease in humans that is characterized by excessive mobilization of neutrophils into the lung. However, the reason for the increased neutrophil burden has not been fully elucidated. In this study we have demonstrate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21060150
DOI: 10.1172/JCI41196
PMCID: PMC2993580

Genes

CXCR1
GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21060150-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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