Article

Structural promiscuity in the human circulatory IgA1 clonal repertoire

2025-11-13

Abstract excerpt

Immunoglobulin A (IgA) is the most abundant antibody in humans, with high concentrations in both mucosae/secretions and circulation. While mucosal IgA has been studied extensively, characterization of human IgA in serum and its distinctive functions lags behind. Circulatory IgA is regularly assumed to be monomeric, despite some reports describing a minor population of J-chain-coupled dimers. Here, we first charted...

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Literature Corpus work: cc3535b0-4ad8-559b-95f3-ef79f7c03e73
DOI: 10.1101/2025.11.13.688237

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