Article
Internal Associations of the Acidic Region of Upstream Binding Factor Control Its Nucleolar Localization.
Molecular and cellular biology - 15 Nov 2017
Ueshima Shuhei, Nagata Kyosuke, Okuwaki Mitsuru
Abstract excerpt
Upstream binding factor (UBF) is a member of the high-mobility group (HMG) box protein family, characterized by multiple HMG boxes and a C-terminal acidic region (AR). UBF is an essential transcription factor for rRNA genes and mediates the formation of transcriptionally active chromatin in the nucleolus. However, it remains unknown how UBF is specifically localized to the nucleolus. Here, we examined the...
Topics
- Binding Sites
- Cell Line
- Cell Nucleolus
- HEK293 Cells
- HMG-Box Domains
- HeLa Cells
- Humans
- Mutation
- Phosphorylation
- Pol1 Transcription Initiation Complex Proteins
- Protein Binding