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Article

A 2-base insertion in exon 5 is a common mutation of the TP53 gene in dogs with histiocytic sarcoma.

The Journal of veterinary medical science - 20 Oct 2017

Asada Hajime, Tsuboi Masaya, Chambers James K, Uchida Kazuyuki, Tomiyasu Hirotaka, Goto-Koshino Yuko, Ohno Koichi, Tsujimoto Hajime

Abstract excerpt

Canine histiocytic sarcoma (HS) is a malignancy originating from the histiocytic cell lineage and characterized by poor response to chemotherapy and short survival time. Mutation of the TP53 gene and its association with poor prognosis has been reported in several canine tumors. However, the mutation of this gene has not been investigated in canine HS. The aim of this study was to examine a TP53 gene mutation in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28867679
DOI: 10.1292/jvms.17-0197
PMCID: PMC5658567

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