Article
Novel p53 tumour suppressor mutations in cases of spindle cell sarcoma, pleomorphic sarcoma and fibrosarcoma in cats.
Veterinary research communications - 1 Jun 1998
Mayr B, Reifinger M, Alton K, Schaffner G
Abstract excerpt
Twenty feline neoplasms were sequenced in the region from exons 5 to 8 for the presence of tumour suppressor gene p53 mutations. In a spindle cell sarcoma of the bladder, a missense mutation (codon 164 AAG-->GAG, lysine-->glutamic acid) in exon 5 was detected. In a pleomorphic sarcoma, a 23 bp de...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cat Diseases
- Cats
- DNA, Neoplasm
- Female
- Fibrosarcoma
- Gene Deletion
- Genes, p53
- Male
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Sarcoma
- Sequence Analysis, DNA
- Skin Neoplasms
- Urinary Bladder Neoplasms