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Article

PTPN11 mutations in canine and human disseminated histiocytic sarcoma.

International journal of cancer - 15 Sept 2020

Hédan Benoit, Rault Mélanie, Abadie Jérôme, Ulvé Ronan, Botherel Nadine, Devauchelle Patrick, Copie-Bergman Christiane, Cadieu Edouard, Parrens Marie, Alten Julia, Zalcman Emmanuelle L, Cario Gunnar, Damaj Gandhi, Mokhtari Karima, Le Loarer Francois, Coulomb-Lhermine Aurore, Derrien Thomas, Hitte Christophe, Bachelot Laura, Breen Matthew, Gilot David, Blay Jean Y, Donadieu Jean, André Catherine

Abstract excerpt

In humans, histiocytic sarcoma (HS) is an aggressive cancer involving histiocytes. Its rarity and heterogeneity explain that treatment remains a challenge. Sharing high clinical and histopathological similarities with human HS, the canine HS is conversely frequent in specific breeds and thus constitutes a unique spontaneous model for human HS to decipher the genetic bases and to explore therapeutic options. We...

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PMID: 32212266
DOI: 10.1002/ijc.32991

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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