Article
TP53 gene mutations in canine osteosarcoma.
Veterinary surgery : VS - 1 Jul 2008
Kirpensteijn Jolle, Kik Marja, Teske Erik, Rutteman Gerard R
Abstract excerpt
OBJECTIVE: To investigate mutations of the TP53 gene in canine osteosarcoma (OS). STUDY DESIGN: Clinical historic cohort study. ANIMALS: Client-owned dogs. METHODS: OS (n=59) were screened for mutations of the complete TP53 gene using polymerase chain reaction and the mutation was analyzed by single-strand conformational polymorphism. Clinical outcome of dogs with TP53-mutated OS were compared with dogs with OS...
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