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Article

A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors.

Scientific reports - 31 Aug 2017

Brænne Ingrid, Willenborg Christina, Tragante Vinicius, Kessler Thorsten, Zeng Lingyao, Reiz Benedikt, Kleinecke Mariana, von Ameln Simon, Willer Cristen J, Laakso Markku, Wild Philipp S, Zeller Tanja, Wallentin Lars, Franks Paul W, Salomaa Veikko, Dehghan Abbas, Meitinger Thomas, Samani Nilesh J, Asselbergs Folkert W, Erdmann Jeanette, Schunkert Heribert

Abstract excerpt

Cyclooxygenase-2 inhibitors (coxibs) are characterized by multiple molecular off-target effects and increased coronary artery disease (CAD) risk. Here, we systematically explored common variants of genes representing molecular targets of coxibs for association with CAD. Given a broad spectrum of pleiotropic effects of coxibs, our intention was to narrow potential mechanisms affecting CAD risk as we hypothesized...

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Identifiers

PMID: 28860667
DOI: 10.1038/s41598-017-10928-4
PMCID: PMC5579257

Genes

CAD
BCAR1
MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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