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In silico genome-wide gene-based association analysis reveals new genes predisposing to coronary artery disease.

Clinical genetics - 1 Jan 2022

Zorkoltseva Irina, Shadrina Alexandra, Belonogova Nadezhda, Kirichenko Anatoly, Tsepilov Yakov, Axenovich Tatiana

Abstract excerpt

Genome-wide association study (GWAS) have identified more than 300 single nucleotide polymorphisms at 163 independent loci associated with coronary artery disease (CAD). However, there is no full understanding about the causal genes for CAD and the mechanisms of their action. We aimed to perform a post GWAS analysis to identify genes whose polymorphism may influence the risk of CAD. Using the UK Biobank GWAS...

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PMID: 34687547
DOI: 10.1111/cge.14073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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