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Article

Notum coordinates synapse development via extracellular regulation of Wingless trans-synaptic signaling.

Development (Cambridge, England) - 1 Oct 2017

Kopke Danielle L, Lima Sofia C, Alexandre Cyrille, Broadie Kendal

Abstract excerpt

Synaptogenesis requires orchestrated communication between pre- and postsynaptic cells via coordinated trans-synaptic signaling across the extracellular synaptomatrix. The first Wnt signaling ligand discovered, Drosophila Wingless (Wg; Wnt1 in mammals), plays crucial roles in synaptic development, regulating synapse architecture as well as functional differentiation. Here, we investigate synaptogenic functions of...

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Identifiers

PMID: 28860114
DOI: 10.1242/dev.148130
PMCID: PMC5665478

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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