Article
Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release.
The Journal of cell biology - 3 Jul 2006
Ahmad-Annuar Azlina, Ciani Lorenza, Simeonidis Iordanis, Herreros Judit, Fredj Naila Ben, Rosso Silvana B, Hall Anita, Brickley Stephen, Salinas Patricia C
Abstract excerpt
Proper dialogue between presynaptic neurons and their targets is essential for correct synaptic assembly and function. At central synapses, Wnt proteins function as retrograde signals to regulate axon remodeling and the accumulation of presynaptic proteins. Loss of Wnt7a function leads to defects in the localization of presynaptic markers and in the morphology of the presynaptic axons. We show that loss of...
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