The Crossroads of Synaptic Growth Signaling, Membrane Traffic and Neurological Disease: Insights from <i>Drosophila</i>

Abstract excerpt

Neurons require target-derived autocrine and paracrine growth factors to maintain proper identity, innervation, homeostasis and survival. Neuronal growth factor signaling is highly dependent on membrane traffic, both for the packaging and release of the growth factors themselves, and for regulation of intracellular signaling by their transmembrane receptors. Here, we review recent findings from the Drosophila...

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