Article
Hepatic Notch1 deletion predisposes to diabetes and steatosis via glucose-6-phosphatase and perilipin-5 upregulation.
Laboratory investigation; a journal of technical methods and pathology - 1 Sept 2016
Bernsmeier Christine, Dill Michael T, Provenzano Angela, Makowska Zuzanna, Krol Ilona, Muscogiuri Giovanna, Semela David, Tornillo Luigi, Marra Fabio, Heim Markus H, Duong François H T
Abstract excerpt
Notch signaling pathways have recently been implicated in the pathogenesis of metabolic diseases. However, the role of hepatic Notch signaling in glucose and lipid metabolism remains unclear and needs further investigation as it might be a candidate therapeutic target in metabolic diseases such as nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD). We used hepatocyte-specific Notch1...
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