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Liver microRNA transcriptome reveals miR-182 as link between type 2 diabetes and fatty liver disease in obesity

1 Dec 2023

Abstract excerpt

Background: The development of obesity-associated comorbidities such as type 2 diabetes (T2D) and hepatic steatosis has been linked to selected microRNAs in individual studies; however, an unbiased genome-wide approach to map T2D induced changes in the miRNAs landscape in human liver samples, and a subsequent robust identification and validation of target genes are still missing. Methods: Liver biopsies from age-...

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PMID: 39037913
DOI: 10.7554/elife.92075

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