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Article

A morphometric study of the spatial patterns of TDP-43 immunoreactive neuronal inclusions in frontotemporal lobar degeneration (FTLD) with progranulin (GRN) mutation.

Histology and histopathology - 1 Feb 2011

Armstrong Richard A, Cairns Nigel J

Abstract excerpt

Mutations of the progranulin (GRN) gene are a major cause of familial frontotemporal lobar degeneration with transactive response (TAR) DNA-binding protein of 43 kDa (TDP-43) proteinopathy (FTLD-TDP). We studied the spatial patterns of TDP-43 immunoreactive neuronal cytoplasmic inclusions (NCI) and neuronal intranuclear inclusions (NII) in histological sections of the frontal and temporal lobe in eight cases of...

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Identifiers

PMID: 21154232
DOI: 10.14670/HH-26.185
PMCID: PMC3017380

Genes

GRN

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Source receipt: pubmed, retrieved 7 Sept 2026.

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