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Article

Pten deletion in adult hippocampal neural stem/progenitor cells causes cellular abnormalities and alters neurogenesis.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 25 Apr 2012

Amiri Anahita, Cho Woosung, Zhou Jing, Birnbaum Shari G, Sinton Christopher M, McKay Renée M, Parada Luis F

Abstract excerpt

Adult neurogenesis persists throughout life in restricted brain regions in mammals and is affected by various physiological and pathological conditions. The tumor suppressor gene Pten is involved in adult neurogenesis and is mutated in a subset of autism patients with macrocephaly; however, the link between the role of PTEN in adult neurogenesis and the etiology of autism has not been studied before. Moreover,...

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Source

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Identifiers

PMID: 22539849
DOI: 10.1523/JNEUROSCI.5462-11.2012
PMCID: PMC6703621

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pten deletion in adult hippocampal neural stem/progenitor cells causes cellular abnormalities and alters neurogenesis.PMID 22539849Read ↗

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