Article
Genetic correlations between intraocular pressure, blood pressure and primary open-angle glaucoma: a multi-cohort analysis.
European journal of human genetics : EJHG - 1 Nov 2017
Aschard Hugues, Kang Jae H, Iglesias Adriana I, Hysi Pirro, Cooke Bailey Jessica N, Khawaja Anthony P, Allingham R Rand, Ashley-Koch Allison, Lee Richard K, Moroi Sayoko E, Brilliant Murray H, Wollstein Gadi, Schuman Joel S, Fingert John H, Budenz Donald L, Realini Tony, Gaasterland Terry, Scott William K, Singh Kuldev, Sit Arthur J, Igo Robert P, Song Yeunjoo E, Hark Lisa, Ritch Robert, Rhee Douglas J, Gulati Vikas, Haven Shane, Vollrath Douglas, Zack Donald J, Medeiros Felipe, Weinreb Robert N, Cheng Ching-Yu, Chasman Daniel I, Christen William G, Pericak-Vance Margaret A, Liu Yutao, Kraft Peter, Richards Julia E, Rosner Bernard A, Hauser Michael A, Klaver Caroline C W, vanDuijn Cornelia M, Haines Jonathan, Wiggs Janey L, Pasquale Louis R
Abstract excerpt
Primary open-angle glaucoma (POAG) is the most common chronic optic neuropathy worldwide. Epidemiological studies show a robust positive relation between intraocular pressure (IOP) and POAG and modest positive association between IOP and blood pressure (BP), while the relation between BP and POAG is controversial. The International Glaucoma Genetics Consortium (n=27 558), the International Consortium on Blood...
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