Article
Common genetic determinants of intraocular pressure and primary open-angle glaucoma.
PLoS genetics - 1 Jan 2012
van Koolwijk Leonieke M E, Ramdas Wishal D, Ikram M Kamran, Jansonius Nomdo M, Pasutto Francesca, Hysi Pirro G, Macgregor Stuart, Janssen Sarah F, Hewitt Alex W, Viswanathan Ananth C, ten Brink Jacoline B, Hosseini S Mohsen, Amin Najaf, Despriet Dominiek D G, Willemse-Assink Jacqueline J M, Kramer Rogier, Rivadeneira Fernando, Struchalin Maksim, Aulchenko Yurii S, Weisschuh Nicole, Zenkel Matthias, Mardin Christian Y, Gramer Eugen, Welge-Lüssen Ulrich, Montgomery Grant W, Carbonaro Francis, Young Terri L, Bellenguez Céline, McGuffin Peter, Foster Paul J, Topouzis Fotis, Mitchell Paul, Wang Jie Jin, Wong Tien Y, Czudowska Monika A, Hofman Albert, Uitterlinden Andre G, Wolfs Roger C W, de Jong Paulus T V M, Oostra Ben A, Paterson Andrew D, Mackey David A, Bergen Arthur A B, Reis André, Hammond Christopher J, Vingerling Johannes R, Lemij Hans G, Klaver Caroline C W, van Duijn Cornelia M
Abstract excerpt
Intraocular pressure (IOP) is a highly heritable risk factor for primary open-angle glaucoma and is the only target for current glaucoma therapy. The genetic factors which determine IOP are largely unknown. We performed a genome-wide association study for IOP in 11,972 participants from 4 independent population-based studies in The Netherlands. We replicated our findings in 7,482 participants from 4 additional...
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