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Article

GWAS-by-subtraction reveals an IOP-independent component of primary open angle glaucoma.

Nature communications - 17 Oct 2024

Huang Yu, Plotnikov Denis, Wang Huan, Shi Danli, Li Cong, Zhang Xueli, Zhang Xiayin, Tang Shulin, Shang Xianwen, Hu Yijun, Yu Honghua, Zhang Hongyang, Guggenheim Jeremy A, He Mingguang

Abstract excerpt

The etiology of primary open angle glaucoma is constituted by both intraocular pressure-dependent and intraocular pressure-independent mechanisms. However, GWASs of traits affecting primary open angle glaucoma through mechanisms independent of intraocular pressure remains limited. Here, we address this gap by subtracting the genetic effects of a GWAS for intraocular pressure from a GWAS for primary open angle...

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Share to Blood Pressure
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Glaucoma and retinal disorders

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Share to Polymorphism, Single Nucleotide

Share to Retinal Imaging and Analysis

Source

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Identifiers

PMID: 39419966
DOI: 10.1038/s41467-024-53331-0
PMCID: PMC11487129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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