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Article

Genome-wide association study and meta-analysis of intraocular pressure.

Human genetics - 1 Jan 2014

Ozel A Bilge, Moroi Sayoko E, Reed David M, Nika Melisa, Schmidt Caroline M, Akbari Sara, Scott Kathleen, Rozsa Frank, Pawar Hemant, Musch David C, Lichter Paul R, Gaasterland Doug, Branham Kari, Gilbert Jesse, Garnai Sarah J, Chen Wei, Othman Mohammad, Heckenlively John, Swaroop Anand, Abecasis Gonçalo, Friedman David S, Zack Don, Ashley-Koch Allison, Ulmer Megan, Kang Jae H, Liu Yutao, Yaspan Brian L, Haines Jonathan, Allingham R Rand, Hauser Michael A, Pasquale Louis, Wiggs Janey, Richards Julia E, Li Jun Z

Abstract excerpt

Elevated intraocular pressure (IOP) is a major risk factor for glaucoma and is influenced by genetic and environmental factors. Recent genome-wide association studies (GWAS) reported associations with IOP at TMCO1 and GAS7, and with primary open-angle glaucoma (POAG) at CDKN2B-AS1, CAV1/CAV2, and SIX1/SIX6. To identify novel genetic variants and replicate the published findings, we performed GWAS and...

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Source

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Identifiers

PMID: 24002674
DOI: 10.1007/s00439-013-1349-5
PMCID: PMC3982323

Genes

TMCO1
CAV1
CAV2
GAS7
SIX1
SIX6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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