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Article

Genetic risk factors associated with ocular perfusion pressure in primary open-angle glaucoma.

Human genomics - 24 Mar 2025

Jin Heejin, Seo Je Hyun, Lee Young, Won Sungho

Abstract excerpt

BACKGROUND: Primary open-angle glaucoma (POAG) is the leading cause of irreversible vision loss. However, its genetic risk factors, such as the vascular hypothesis of POAG, remain unclear. Here, we aimed to explore the genetic associations between mean ocular perfusion pressure (MOPP) and POAG. We performed genome-wide analysis with gene-based analysis from the UK Biobank (N = 459,195), which includes genetic...

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Share to Genetic Predisposition to Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glaucoma, Open-Angle

Share to Intraocular Pressure

Share to Mendelian Randomization Analysis

Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 40128813
DOI: 10.1186/s40246-025-00738-5
PMCID: PMC11934579

Genes

CEP85L
GRIA4
GRIN2A
MAGI1
POU6F2
RBFOX1
RBMS1
RBMS3
RBPMS
TRHDE
TUBB3
ZFHX3
ZMAT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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