Article
Methylomic profiling and replication implicates deregulation of PCSK9 in alcohol use disorder.
Molecular psychiatry - 1 Sept 2018
Lohoff F W, Sorcher J L, Rosen A D, Mauro K L, Fanelli R R, Momenan R, Hodgkinson C A, Vendruscolo L F, Koob G F, Schwandt M, George D T, Jones I S, Holmes A, Zhou Z, Xu M-J, Gao B, Sun H, Phillips M J, Muench C, Kaminsky Z A
Abstract excerpt
Alcohol use disorder (AUD) is a common and chronic disorder with substantial effects on personal and public health. The underlying pathophysiology is poorly understood but strong evidence suggests significant roles of both genetic and epigenetic components. Given that alcohol affects many organ systems, we performed a cross-tissue and cross-phenotypic analysis of genome-wide methylomic variation in AUD using...
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