Article
Epigenetics of alcohol use disorder-A review of recent advances in DNA methylation profiling.
Addiction biology - 1 Nov 2021
Longley Martha J, Lee Jisoo, Jung Jeesun, Lohoff Falk W
Abstract excerpt
Alcohol use disorder (AUD) is a major contributor to morbidity and mortality worldwide. Although there is a heritable component, the etiology of AUD is complex and can involve environmental exposures like trauma and can be associated with many different patterns of alcohol consumption. Epigenetic modifications, which can mediate the influence of genetic variants and environmental variables on gene expression,...
Topics
- Alcoholism
- DNA Methylation
- Epigenesis, Genetic
- Gene Expression Profiling
- Genome-Wide Association Study
- Humans
- Phenotype
- Promoter Regions, Genetic