Article
Methylene tetrahydrofolate reductase gene polymorphism in Egyptian children with acute lymphoblastic leukemia.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Jan 2010
Tantawy Azza A G, El-Bostany Eman A, Adly Amira A M, Abou El Asrar Mohammed, El-Ghouroury Eman A, Abdulghaffar Esmat E
Abstract excerpt
Genetic variations of the enzymes involved in chemotherapy metabolism in cancer patients may play a role in determining relapse and toxicity risks. Methotrexate is a key drug in acute lymphoblastic leukemia (ALL) treatment; it inhibits DNA replication by blocking the conversion of 5,10 methylene tetrahydrofolate to 5-methylene tetrahydrofolate by methylene tetrahydrofolate reductase (MTHFR). MTHFR is central to...
Topics
- Alleles
- Antineoplastic Combined Chemotherapy Protocols
- Asparaginase
- Chemical and Drug Induced Liver Injury
- Child
- Child, Preschool
- Cyclophosphamide
- Cytarabine
- Daunorubicin
- Egypt