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Article

DNA repair gene XRCC1 polymorphisms in childhood acute lymphoblastic leukemia.

Cancer letters - 10 Jan 2005

Joseph Thomas, Kusumakumary P, Chacko Priya, Abraham Annie, Pillai M Radhakrishna

Abstract excerpt

Defective DNA repair has been reported to be a risk factor for various malignancies. Genetic polymorphisms of DNA repair genes are thought to result in different phenotypic features compared to the wild type. Genetic polymorphisms in XRCC1 gene could, through alteration of protein structure, lead to defective functioning of DNA Polbeta, PARP and LIG3 enzymes resulting in defective DNA repair and increased risk of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15596292
DOI: 10.1016/j.canlet.2004.06.055

Genes

XRCC1
LIG3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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