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Article

Genomic and Epigenomic Heterogeneity of Hepatocellular Carcinoma.

Cancer research - 1 May 2017

Lin De-Chen, Mayakonda Anand, Dinh Huy Q, Huang Pinbo, Lin Lehang, Liu Xiaoping, Ding Ling-Wen, Wang Jie, Berman Benjamin P, Song Er-Wei, Yin Dong, Koeffler H Phillip

Abstract excerpt

Understanding the intratumoral heterogeneity of hepatocellular carcinoma is instructive for developing personalized therapy and identifying molecular biomarkers. Here we applied whole-exome sequencing to 69 samples from 11 patients to resolve the genetic architecture of subclonal diversification. Spatial genomic diversity was found in all 11 hepatocellular carcinoma cases, with 29% of driver mutations being...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28302680
DOI: 10.1158/0008-5472.CAN-16-2822
PMCID: PMC5413372

Genes

KIT
NOTCH2
STAG2
SYK
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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