The tryptophan biosynthetic pathway is essential for Mycobacterium tuberculosis to cause disease.

doi:10.1042/BST20200194

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Article

The tryptophan biosynthetic pathway is essential for Mycobacterium tuberculosis to cause disease.

Biochemical Society transactions - 30 Oct 2020

Lott J Shaun

Abstract excerpt

Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), is the most significant cause of death from a single infectious agent worldwide. Antibiotic-resistant strains of M. tuberculosis represent a threat to effective treatment, and the long duration, toxicity and complexity of current chemotherapy for antibiotic-resistant disease presents a need for new therapeutic approaches with novel modes of...

Topics

Allosteric Site
Animals
Anti-Bacterial Agents
Antitubercular Agents
Biosynthetic Pathways
Catalysis
Disease Models, Animal
Drug Resistance, Multiple
Humans
Indoleamine-Pyrrole 2,3,-Dioxygenase
Inhibitory Concentration 50
Mice
Mutation
Mycobacterium tuberculosis
Phagocytosis
Phenotype
Tryptophan
Tuberculosis

Source

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Identifiers

PMID: 32915193
DOI: 10.1042/BST20200194
PMCID: PMC7609029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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