Article
The tryptophan synthase multienzyme complex: exploring structure-function relationships with X-ray crystallography and mutagenesis.
Bio/technology (Nature Publishing Company) - 1 Jan 1990
Hyde C C, Miles E W
Abstract excerpt
The bifunctional tryptophan synthase alpha 2 beta 2 complex that catalyzes the final two reactions in tryptophan biosynthesis is a classic example of a multienzyme complex that "channels" a metabolic intermediate (indole) between two active sites. The three-dimensional structure of the alpha 2 beta 2 complex from Salmonella typhimurium reveals that the four polypeptide subunits are arranged in an extended alpha...
Topics
- Crystallography
- Mutation
- Protein Binding
- Protein Conformation
- Salmonella typhimurium
- Tryptophan Synthase