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Article

Characterization of the putative tryptophan synthase beta-subunit from Mycobacterium tuberculosis.

Acta biochimica et biophysica Sinica - 1 May 2009

Shen Hongbo, Yang Yanping, Wang Feifei, Zhang Ying, Ye Naihao, Xu Shengfeng, Wang Honghai

Abstract excerpt

The increasing emergence of drug-resistant tuberculosis (TB) poses a serious threat to the control of this disease. It is in urgent need to develop new TB drugs. Tryptophan biosynthetic pathway plays an important role in the growth and replication of Mycobacterium tuberculosis (Mtb). The beta-subunit of tryptophan synthase (TrpB) catalyzes the last step of the tryptophan biosynthetic pathway, and it might be a...

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PMID: 19430702
DOI: 10.1093/abbs/gmp017

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