Identification of KasA as the cellular target of an anti-tubercular scaffold.

doi:10.1038/ncomms12581

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Identification of KasA as the cellular target of an anti-tubercular scaffold.

Nature communications - 1 Sept 2016

Abrahams Katherine A, Chung Chun-Wa, Ghidelli-Disse Sonja, Rullas Joaquín, Rebollo-López María José, Gurcha Sudagar S, Cox Jonathan A G, Mendoza Alfonso, Jiménez-Navarro Elena, Martínez-Martínez María Santos, Neu Margarete, Shillings Anthony, Homes Paul, Argyrou Argyrides, Casanueva Ruth, Loman Nicholas J, Moynihan Patrick J, Lelièvre Joël, Selenski Carolyn, Axtman Matthew, Kremer Laurent, Bantscheff Marcus, Angulo-Barturen Iñigo, Izquierdo Mónica Cacho, Cammack Nicholas C, Drewes Gerard, Ballell Lluis, Barros David, Besra Gurdyal S, Bates Robert H

Abstract excerpt

Phenotypic screens for bactericidal compounds are starting to yield promising hits against tuberculosis. In this regard, whole-genome sequencing of spontaneous resistant mutants generated against an indazole sulfonamide (GSK3011724A) identifies several specific single-nucleotide polymorphisms in the essential Mycobacterium tuberculosis β-ketoacyl synthase (kas) A gene. Here, this genomic-based target assignment...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antitubercular Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Bacterial

Share to Indazoles

Share to Mice, Inbred C57BL

Share to Microbial Sensitivity Tests

Share to Mycobacterium tuberculosis

Share to Sulfonamides

Share to Tuberculosis, Pulmonary

Source

Open in PubMed Open full text

Identifiers

PMID: 27581223
DOI: 10.1038/ncomms12581
PMCID: PMC5025758

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of KasA as the cellular target of an anti-tubercular scaffold.PMID 27581223Read ↗

Target Identification in Anti-Tuberculosis Drug DiscoverySemantic proximity Read ↗

Hit Compounds and Associated Targets in Intracellular Mycobacterium tuberculosis.Semantic proximity Read ↗

The phenotypic landscape of the mycobacterial cellSemantic proximity Read ↗

Mutations in dnaA and a cryptic interaction site increase drug resistance in Mycobacterium tuberculosis.Semantic proximity Read ↗

Tuberculosis drug discovery in the post‐post‐genomic eraSemantic proximity Read ↗

Direct inhibitors of InhA with efficacy similar or superior to isoniazid in novel drug regimens for tuberculosisSemantic proximity Read ↗

CRISPR interference identifies vulnerable cellular pathways with bactericidal phenotypes in Mycobacterium tuberculosis.Semantic proximity Read ↗

State-of-the-art strategies to prioritize Mycobacterium tuberculosis drug targets for drug discovery using a subtractive genomics approachSemantic proximity Read ↗

Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis.Semantic proximity Read ↗

Discovery and functional characterization of katG mutations mediating Isoniazid resistance in Mycobacterium tuberculosis.Semantic proximity Read ↗

Strategies in anti-Mycobacterium tuberculosis drug discovery based on phenotypic screeningSemantic proximity Read ↗

Identification and Validation of Novel Drug Targets in TuberculosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.