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Article

High-depth sequencing of paired primary and metastatic tumours: Implications for personalised medicine.

European journal of cancer (Oxford, England : 1990) - 1 Oct 2017

Grellety T, Lucchesi C, Hostein I, Auzanneau C, Khalifa E, Soubeyran I, Italiano A

Abstract excerpt

BACKGROUND: Next-generation sequencing of large panel of genes had been associated with clinical benefit in a significant proportion of patients with advanced cancer. However, the molecular profile of the primary tumour from the initial surgical specimen might significantly differ from the molecular profile in a tumour sample obtained from a biopsy of a metastatic site. PATIENTS AND METHODS: We compare the...

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Identifiers

PMID: 28841542
DOI: 10.1016/j.ejca.2017.07.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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