Comparative analysis of primary tumour and matched metastases in colorectal cancer patients: evaluation of concordance between genomic and transcriptional profiles.

doi:10.1016/j.ejca.2015.02.012

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Article

Comparative analysis of primary tumour and matched metastases in colorectal cancer patients: evaluation of concordance between genomic and transcriptional profiles.

European journal of cancer (Oxford, England : 1990) - 1 May 2015

Vignot Stéphane, Lefebvre Céline, Frampton Garrett M, Meurice Guillaume, Yelensky Roman, Palmer Gary, Capron Frédérique, Lazar Vladimir, Hannoun Laurent, Miller Vincent A, André Fabrice, Stephens Philip J, Soria Jean-Charles, Spano Jean-Philippe

Abstract excerpt

PURPOSE: Focal and temporal tumour heterogeneity can represent a major challenge for biology-guided therapies. This study proposes to investigative molecular discrepancies between primary colorectal cancer (CRC) samples and matched metastases. EXPERIMENTAL DESIGN: Surgical samples from primary and matched metastatic tissues from 13 CRC patients along with their adjacent normal tissue were evaluated. A mutational...

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PMID: 25797355
DOI: 10.1016/j.ejca.2015.02.012

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