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Article

Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain

1 Jul 2018

Abstract excerpt

The mammalian brain undergoes sexual differentiation by gonadal hormones during the perinatal critical period. However, the machinery at earlier stages has not been well studied. We found that Ptf1a is expressed in certain neuroepithelial cells and immature neurons around the third ventricle that give rise to various neurons in several hypothalamic nuclei. We show that conditional Ptf1a-deficient mice (Ptf1a cKO)...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Genetics and Neurodevelopmental Disorders
Share to Hypothalamic control of reproductive hormones

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PMID: 29972793
DOI: 10.1016/j.celrep.2018.06.010

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