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Article

Identification of a functional SNP in the 3'UTR of CXCR2 that is associated with reduced risk of lung cancer.

Cancer research - 1 Feb 2015

Ryan Bríd M, Robles Ana I, McClary Andrew C, Haznadar Majda, Bowman Elise D, Pine Sharon R, Brown Derek, Khan Mohammed, Shiraishi Kouya, Kohno Takashi, Okayama Hirokazu, Modali Ramakrishna, Yokota Jun, Harris Curtis C

Abstract excerpt

Global changes in gene expression accompany the development of cancer. Thus, inherited variants in miRNA-binding sites are likely candidates for conferring inherited susceptibility. Using an in silico approach, we compiled a comprehensive list of SNPs predicted to modulate miRNA binding in genes from several key lung cancer pathways. We then investigated whether these SNPs were associated with lung cancer risk in...

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Identifiers

PMID: 25480945
DOI: 10.1158/0008-5472.CAN-14-2101
PMCID: PMC4315715

Genes

CXCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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