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Article

Impact of coding and non-coding SNPs in the FZD8 gene on structural and functional alterations associated with tumorigenesis: A multi-faceted computational approach.

Computers in biology and medicine - 1 Apr 2026

Mondal Amalesh, Paul Debarati, Mondal Tithi, Goswami Achintya Mohan

Abstract excerpt

FZD8, a GPCR, is involved in various physiological processes, such as cell differentiation, bone growth and stem cell regulation, by binding to various Wnt ligands. Though FZD receptors have low mutation rates in cancer, aberrant Wnt or FZD expression leads to deregulated Wnt/FZD signaling pathways that may result in tumorigenesis. The structural and functional effects of most of the coding and non-coding SNPs of...

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Source

Identifiers

PMID: 41740485
DOI: 10.1016/j.compbiomed.2026.111563

Genes

FZD8
AGO2
E2F6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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