Article
Schizophrenia risk variants affecting microRNA function and site-specific regulation of NT5C2 by miR-206.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Sept 2016
Hauberg Mads Engel, Holm-Nielsen Marie Hebsgaard, Mattheisen Manuel, Askou Anne Louise, Grove Jakob, Børglum Anders Dupont, Corydon Thomas Juhl
Abstract excerpt
Despite the identification of numerous schizophrenia-associated genetic variants, few have been examined functionally to identify and characterize the causal variants. To mitigate this, we aimed at identifying functional variants affecting miRNA function. Using data from a large-scale genome-wide association study of schizophrenia, we looked for schizophrenia risk variants altering either miRNA binding sites,...
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