A Regulatory MDM4 Genetic Variant Locating in the Binding Sequence of Multiple MicroRNAs Contributes to Susceptibility of Small Cell Lung Cancer.

doi:10.1371/journal.pone.0135647

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Article

A Regulatory MDM4 Genetic Variant Locating in the Binding Sequence of Multiple MicroRNAs Contributes to Susceptibility of Small Cell Lung Cancer.

PloS one - 1 Jan 2015

Gao Feng, Xiong Xiangyu, Pan Wenting, Yang Xinyu, Zhou Changchun, Yuan Qipeng, Zhou Liqing, Yang Ming

Abstract excerpt

A functional rs4245739 A>C single nucleotide polymorphism (SNP) locating in the MDM43'-untranslated (3'-UTR) region creates a miR-191-5p or miR-887-3p targeting sites. This change results in decreased expression of oncogene MDM4. Therefore, we examined the association between this SNP and small cell lung cancer (SCLC) risk as well as its regulatory function in SCLC cells. Genotypes were determined in two...

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PMID: 26274820
DOI: 10.1371/journal.pone.0135647
PMCID: PMC4537101

Genes

MDM4

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