Article
Prevalence of homologous recombination biomarkers in multiple tumor types: an observational study.
Future oncology (London, England) - 1 Jan 2024
Chen Cai, Dettman Elisha J, Zhou Wei, Gozman Alexander, Jin Fan, Lee Liam C, Ren Yixin, Zhou Heng, Cristescu Razvan, Shao Changxia
Abstract excerpt
Aim: To determine the prevalence of deleterious mutations in BRCA1 and BRCA2 and in 13 genes involved in homologous recombination repair (HRR), the prevalence of genomic loss of heterozygosity and the allelic and hereditary status of BRCA1, BRCA2 and other HRR gene mutations in multiple solid tumor types.Patients & methods: This was a retrospective observational study of patients with an advanced/metastatic...
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