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Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer

9 Oct 2012

Abstract excerpt

BACKGROUND: Defects in BRCA1, BRCA2, and other members of the homologous recombination pathway have potential therapeutic relevance when used to support agents that introduce or exploit double-stranded DNA breaks. This study examines the association between homologous recombination defects and genomic patterns of loss of heterozygosity (LOH). METHODS: Ovarian tumours from two independent data sets were...

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PMID: 23047548
DOI: 10.1038/bjc.2012.451

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