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Article

Diagnosis of Ovarian Carcinoma Homologous Recombination DNA Repair Deficiency From Targeted Gene Capture Oncology Assays.

JCO precision oncology - 1 May 2023

Krumm Niklas, Khasnavis Nithisha S, Radke Marc, Banda Kalyan, Davies Helen R, Pennil Christopher, McLean Kathryn, Paulson Vera A, Konnick Eric Q, Johnson Winslow C, Huff Grogan, Nik-Zainal Serena, Swisher Elizabeth M, Lockwood Christina M, Salipante Stephen J

Abstract excerpt

PURPOSE: Homologous recombination DNA repair deficiency (HRD) is a therapeutic biomarker for sensitivity to platinum and poly(ADP-ribose) polymerase inhibitor therapies in breast and ovarian cancers. Several molecular phenotypes and diagnostic strategies have been developed to assess HRD; however, their clinical implementation remains both technically challenging and methodologically unstandardized. METHODS: We...

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Identifiers

PMID: 37196218
DOI: 10.1200/PO.22.00720
PMCID: PMC10309534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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